April 13, 2026 · Journal of the American Society of Nephrology : JASN · DOI: 10.1681/ASN.0000001099

Comparative Effectiveness of Different Influenza Vaccine Formulations among Patients Undergoing Maintenance Hemodialysis

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The authors aimed to compare the effectiveness of different influenza vaccine formulations in preventing influenza-related outcomes among older adults undergoing maintenance hemodialysis. Their study found that high-dose and cell culture-based vaccines offered modestly increased protection against influenza and related hospitalizations compared to the standard-dose vaccine, while the effects of adjuvanted and recombinant vaccines were less clear. Overall, the findings suggest that certain enhanced vaccine formulations may be beneficial for this vulnerable population.

John W Davis, J Bradley Layton, John M Sahrmann, Katelin B Nickel, Vikas R Dharnidharka, David J Weber, Anne M Butler

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