Gestational Ketosis Compromises Nephron Endowment and Long-Term Kidney Function in Offspring
Listen to this summary
The authors investigate the impact of maternal ketosis, induced by a ketogenic diet or β-hydroxybutyrate supplementation, on fetal kidney development and long-term kidney function in offspring. Their findings reveal that maternal ketosis leads to a significant reduction in nephron number and impaired kidney function in offspring, attributed to disrupted nephrogenesis through the suppression of c-Myc signaling and activation of inflammatory pathways in nephron progenitor cells.
This is one of 33,000+ journals available on OSLR. Try it free for 14 days.
Free 14-day trial. 33,000+ journals. Cancel anytime.
More from Journal of the American Society of Nephrology : JASN
View all →May 8, 2026 · Journal of the American Society of Nephrology : JASN
Purine Metabolism Regulates the Severity of APOL1 Nephropathy
May 7, 2026 · Journal of the American Society of Nephrology : JASN
Microvascular Inflammation in Kidney Transplantation
May 1, 2026 · Journal of the American Society of Nephrology : JASN
Integrating Genomics and Proteomics to Identify Causal Proteins and Biologic Pathways for Incident Atrial Fibrillation in CKD
Apr 23, 2026 · Journal of the American Society of Nephrology : JASN
Normalization of nCounter Gene Expression Data Alters Molecular Diagnostics in Kidney Transplantation
Apr 21, 2026 · Journal of the American Society of Nephrology : JASN
eGFR Discordance and its Association with Outcomes following Allogeneic Hematopoietic Stem Cell Transplantation and Adoptive T-Cell Therapies
Apr 17, 2026 · Journal of the American Society of Nephrology : JASN
Computational Frontiers in Arteriovenous Fistula Maturation: A Review of Fluid Dynamics and Machine Learning Models
More in Internal Medicine
View all →May 10, 2026 · JAMA
Digoxin in Patients With Symptomatic Rheumatic Heart Disease: A Randomized Clinical Trial
May 10, 2026 · European heart journal
Blinded withdrawal of randomized treatment with low-dose digoxin or placebo in patients with heart failure: the DECISION trial
May 10, 2026 · Lancet (London, England)
Endovascular thrombectomy for patients with large-core ischaemic stroke presenting up to 24 h after onset (ATLAS): a systematic review and individual patient data meta-analysis with central imaging adjudication
May 10, 2026 · European heart journal
Renin-angiotensin-aldosterone system inhibition and haemocompatibility-related adverse events in patients with durable left ventricular assist device: the MOMENTUM-3 trial
May 10, 2026 · JAMA
Efficacy and Safety of Digitalis Glycosides in Heart Failure: A Meta-Analysis
May 10, 2026 · Lancet (London, England)
Impact of introducing RTS,S/AS01<sub>E</sub> malaria vaccine on mortality in young children in Ghana, Kenya, and Malawi: an observational evaluation of a cluster-randomised implementation programme
"Oslr has become part of my weekly routine on my day off. The clinical relevance of the summaries is outstanding — I'd rate it 9/10. Being able to consume research hands-free is a huge advantage for busy physicians."
Dr. Jennifer Thompson
Portland, OR
Stay current without falling behind
33,000+ journals. 3-minute audio summaries. Free for 14 days.
