Integrating Genomics and Proteomics to Identify Causal Proteins and Biologic Pathways for Incident Atrial Fibrillation in CKD
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The authors aimed to identify causal proteins and biological pathways linking chronic kidney disease (CKD) to incident atrial fibrillation (AF) and to develop a predictive model for AF risk in CKD patients. Through the analysis of plasma proteins in two cohorts, they discovered three proteins (NELL1, CILP2, and MMP12) associated with AF and found significant overlap in pathways related to both AF and left atrial enlargement. Additionally, they created a multi-protein risk score for AF that demonstrated comparable predictive performance to existing clinical risk models.
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