Microvascular Inflammation in Kidney Transplantation

The authors aimed to determine the independent prognostic significance of microvascular inflammation, specifically glomerulitis and peritubular capillaritis (g+ptc≥2), in kidney transplant recipients, particularly in the absence of donor-specific anti-HLA antibodies (DSA). Their study found that while g+ptc≥2 was associated with higher rates of death-censored allograft loss, it did not independently predict worse outcomes when accounting for concurrent T-cell-mediated rejection (TCMR) and de novo DSA events. This suggests that g+ptc≥2 alone may not be a reliable indicator of long-term graft survival in the context of modern immunosuppressive therapy.