April 24, 2026 · Gastroenterology · DOI: 10.1053/j.gastro.2026.02.005

Functional Esophageal Disorders

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The authors investigate the underlying mechanisms of functional esophageal disorders, which present symptoms like heartburn and dysphagia without structural abnormalities. They propose that visceral hypersensitivity and altered neuropsychological processing contribute to these symptoms, and emphasize the need for further research into the neurobiological factors involved to develop more effective treatments.

C Prakash Gyawali, Sabine Roman, Frank Zerbib, Edoardo V Savarino, Shobna Bhatia, Ronnie Fass, John E Pandolfino

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