Norepinephrine promotes tumour cell aggressiveness and NK cell ferroptosis via ADRB2 in intrahepatic cholangiocarcinoma with perineural invasion
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The authors investigate the role of sympathetic signaling, specifically norepinephrine (NE) and its interaction with ADRB2, in promoting tumor aggressiveness and inducing ferroptosis in natural killer (NK) cells within intrahepatic cholangiocarcinoma (iCCA) characterized by perineural invasion (PNI). They reveal that NE enhances tumor progression through the upregulation of MDK and decreases NK cell infiltration, suggesting that targeting β-adrenergic signaling could be a potential therapeutic strategy for managing PNI+ iCCA.
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