JOSD1 drives hepatocellular carcinoma malignancy by modulating the ubiquitination-lactylation switch on PGAM1
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The authors investigate the role of the deubiquitinase JOSD1 in the metabolic reprogramming of hepatocellular carcinoma (HCC) and its impact on tumor progression and immune response. They find that JOSD1 enhances glycolysis by modulating the ubiquitination-lactylation switch on PGAM1, leading to immune suppression and poor prognosis. Targeting JOSD1 may offer a promising therapeutic approach to improve treatment outcomes in HCC.
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