Metagenomic identification of gut microbiome signatures for accurate diagnosis and prognostic prediction of Epstein-Barr virus-associated nasopharyngeal carcinoma
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The authors aimed to investigate the relationship between gut microbiome alterations and Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma (NPC) to enhance diagnostic and prognostic capabilities. Their findings revealed significant dysbiosis in the gut microbiome of NPC patients, with specific microbial species correlating with EBV DNA levels and patient mortality. The study demonstrates that microbiome-based diagnostic tools, especially when combined with EBV markers, show strong potential for improving NPC diagnosis and understanding its association with an immune-suppressive tumor microenvironment.
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