The UK experience with hepatitis B immunoglobulin use following liver transplantation: wide variation in practice despite evidence supporting cost-effective HBIG-free prophylaxis
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This study investigates the current practices and outcomes of hepatitis B immunoglobulin (HBIG) use for prophylaxis against hepatitis B virus recurrence following liver transplantation in the UK. The authors found significant variability in HBIG protocols among transplant centers, with most patients receiving HBIG regardless of their recurrence risk, yet the findings suggest that HBIG maintenance-free strategies could be both feasible and cost-effective, as they do not significantly impact patient outcomes. The study calls for further prospective research to validate these results and promote broader adoption of HBIG-free approaches.
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