From tablets to targeted therapy: the APHRODITE era in male infertility

The authors explore whether the newly proposed APHRODITE criteria can improve the treatment of idiopathic male infertility by transitioning from empirical oral therapies to targeted gonadotropin therapy. They argue that this biologically driven approach, akin to advancements in ovarian stimulation for IVF, may enhance treatment outcomes by better aligning interventions with individual hormonal profiles. The article emphasizes the need for future prospective trials to validate the effectiveness of these criteria and compare the efficacy of traditional oral agents with injectable gonadotropins.