February 20, 2026 · Reproductive biology and endocrinology : RB&E · DOI: 10.1186/s12958-026-01535-y

Management of infertility in women with hypothalamic hypogonadotropic hypogonadism: an expert opinion

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The authors aim to provide expert recommendations for managing infertility in women with hypothalamic hypogonadotropic hypogonadism (HH) when pulsatile GnRH therapy is unavailable. They emphasize the importance of optimizing stimulation with exogenous gonadotropins based on the underlying cause of HH and highlight the necessity of luteal phase support to enhance corpus luteum function, thereby improving fertility outcomes.

Geoffroy Robin, Lorraine Maitrot-Mantelet, Sophie Dubourdieu, Bérengère Kiehl-Bigot, Maria Katsogiannou, Michel De Vos, Sophie Christin-Maitre

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