May 9, 2026 · Reproductive biology and endocrinology : RB&E · DOI: 10.1186/s12958-026-01562-9

Serum trace and heavy metal exposure and IVF/ICSI outcomes: modifying effects of maternal diet in a prospective cohort

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The authors aimed to investigate the associations between serum concentrations of ten trace and heavy metals and outcomes of IVF/ICSI, while also examining how maternal dietary patterns might modify these relationships. The study found that higher levels of magnesium and calcium were linked to improved embryo quality, whereas elevated lead levels negatively impacted embryo rates. Additionally, dietary habits, particularly high caffeine consumption, influenced these associations, suggesting that optimizing maternal diet could enhance resilience against metal-related reproductive risks.

Yali Huang, Jing Li, Shengli Lin, Nidong Li, Yingxin Zhu, Linlin Wang, Wei Guo, Lixue Chen, Rong Li, Jie Qiao, Ying Wang

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