April 14, 2026 · Reproductive biology and endocrinology : RB&E · DOI: 10.1186/s12958-026-01548-7

HFTMSCs alleviate uterine fibrosis and restore fertility in intrauterine adhesion models

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The authors investigate the potential of human fallopian tube-derived mesenchymal stem cells (HFTMSCs) in treating intrauterine adhesions (IUA) to alleviate uterine fibrosis and restore fertility. Their findings indicate that the combination of HFTMSCs and estradiol significantly enhances endometrial regeneration, improves structural integrity, and recovers fertility in IUA mouse models, outperforming individual treatments. This study highlights the synergistic effects of HFTMSCs and estradiol in addressing the challenges posed by IUA.

Xitang Yang, Jingwen Guo, Bangyu Ouyang, Liling He, Shulian Mao, Jinhua Li, Weiwei Sun, Xue Chen, XiaoLi Yu, Hua Guo

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