May 1, 2026 · Reproductive biology and endocrinology : RB&E · DOI: 10.1186/s12958-026-01561-w

Real-time intrauterine dissolved oxygen dynamics across the luteal phase: a potential non-invasive functional biomarker of endometrial status

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The authors investigate whether real-time measurements of intrauterine dissolved oxygen (pO₂) during the luteal phase could serve as a non-invasive biomarker for assessing endometrial readiness in women undergoing assisted reproduction. Their pilot study identifies distinct oxygenation patterns, with some participants exhibiting a mid-luteal peak in pO₂, which may correlate with endometrial function. The findings suggest that further research is needed to validate the predictive value of intrauterine oxygen profiling for implantation success and live birth outcomes.

Anna Teixidó Troyano, Melchor Carbonell Socias, Carmen Cabeza Oliver, Elisabeth Sanfeliu de España, Vicenç Font Zabalia, Lidia Illan Hernandez, Maria Antonia Perelló Barceló, Maria Luisa Pancorbo Lerma, Elisabet Robert Marchal, Manel Mendoza Cobaleda, Roger Gallart Agut, Luis Manuel Artiles Martínez, Monica Rodríguez de la Vega Otazo, Anna Suy Franch, Julio Herrero García

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