Testosterone modifies U-Shaped association of eGFR with all-cause mortality in Chinese female centenarians: a prospective cohort study

This study investigates the relationship between estimated glomerular filtration rate (eGFR) and all-cause mortality in female centenarians, with a particular focus on the role of testosterone. The authors found a U-shaped association between eGFR and mortality, indicating that lower eGFR levels are linked to increased mortality risk, and higher testosterone levels may mitigate this risk. These findings suggest that testosterone could influence the kidney function-mortality relationship in this age group, warranting further exploration of causality.