January 22, 2026 · Reproductive biology and endocrinology : RB&E · DOI: 10.1186/s12958-026-01527-y

Impact of ovarian stimulation duration in GnRH antagonist protocols on the cumulative ongoing pregnancy rate in women with normal ovarian reserve: a cohort study

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The study aimed to determine whether the duration of ovarian stimulation in GnRH antagonist IVF/ICSI protocols affects cumulative ongoing pregnancy rates (COPR) in women with normal ovarian reserve. Analyzing 1456 cycles, the authors found that stimulation duration did not significantly influence COPR, suggesting that factors like age and AMH levels are more critical in predicting pregnancy outcomes. These results advocate for a personalized approach to trigger timing based on ovarian response rather than the length of stimulation.

Leah Cohen Aloro, Emine Saïs, Céleste Becquart, Hélène Thomas, Fatoumata Souare, Ines Sellami, Anne Mayeur, Laetitia Hesters, Michaël Grynberg, Charlotte Sonigo

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