FMR1-Associated Diminished Ovarian Reserve: Reduced Oocyte Yield Without Loss of Per-Embryo Ploidy
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The authors aimed to investigate whether diminished ovarian reserve in FMR1 premutation carriers is solely a quantitative issue or if it also affects per-embryo chromosomal competence, particularly regarding embryo aneuploidy risk. Their findings indicate that while FMR1 premutation carriers have reduced ovarian reserve and lower early embryology outcomes, the per-embryo euploidy rates are comparable to matched non-carriers, suggesting that the chromosomal competence of embryos is not impaired despite a lower oocyte yield.
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