Fertility and sterility
Audio Summaries

FMR1-Associated Diminished Ovarian Reserve: Reduced Oocyte Yield Without Loss of Per-Embryo Ploidy

Sep 22, 2026

The authors aimed to investigate whether diminished ovarian reserve in FMR1 premutation carriers is solely a quantitative issue or if it also affects per-embryo chromosomal competence, particularly regarding embryo aneuploidy risk. Their findings indicate that while FMR1 premutation carriers have reduced ovarian reserve and lower early embryology outcomes, the per-embryo euploidy rates are comparable to matched non-carriers, suggesting that the chromosomal competence of embryos is not impaired despite a lower oocyte yield.

Precision Surgery for Colorectal Deep Endometriosis: Strategies for Complete Excision Without Segmental Resection

Sep 21, 2026

The authors aim to evaluate the effectiveness of robotic surgery combined with intraoperative ultrasound in achieving complete excision of colorectal deep endometriosis while avoiding segmental bowel resection. Their findings demonstrate that this approach allows for precise localization and real-time assessment of lesions, successfully preserving bowel integrity and reducing the risk of recurrence by enabling immediate re-excision of any residual disease. Overall, the study highlights the potential of this surgical strategy to optimize outcomes for patients with colorectal deep endometriosis.

Expanding Horizons in Fertility Preservation: Diverse Populations, Emerging Indications, and Ethical Considerations

Sep 21, 2026

The authors explore the evolving landscape of fertility preservation beyond traditional cancer treatment, addressing diverse populations such as transgender individuals, prepubescent girls, and those with genetic predispositions to ovarian insufficiency. They aim to identify optimal intervention strategies and outcomes while considering ethical implications, access, and psychosocial factors, ultimately advocating for personalized approaches in fertility preservation as indications expand.

IVF outcomes and aneuploidy rates in BRCA pathogenic variant carriers undergoing preimplantation genetic testing

Sep 17, 2026

The authors aimed to evaluate IVF outcomes and aneuploidy rates in women with BRCA pathogenic variants undergoing preimplantation genetic testing (PGT) compared to those with other monogenic disorders. The study found that while ovarian response and IVF outcomes were similar between BRCA carriers and controls, aneuploidy rates were significantly lower in BRCA2 carriers compared to controls, while BRCA1 carriers showed comparable rates. These results suggest that BRCA pathogenic variants do not adversely affect reproductive outcomes, providing reassurance for BRCA carriers considering IVF.

PMOS beyond the reproductive years: menopause and long-term health outcomes

Sep 7, 2026

The authors investigate how Polyendocrine Metabolic Ovarian Syndrome (PMOS) affects women's health beyond their reproductive years, particularly focusing on the long-term implications for metabolic dysfunction, cardiovascular disease, and psychological health. They highlight the challenges in diagnosing PMOS in older women due to symptom improvements that do not indicate resolution of the disorder, emphasizing the need for more longitudinal studies to better understand its lifelong impact. The review calls for increased awareness and multidisciplinary management of PMOS as a chronic condition throughout a woman's life.

Age-Associated Primordial Follicle Density in Human Ovarian Cortical Tissue from Post-Pubertal Females Undergoing Ovarian Tissue Cryopreservation and Transplantation: A Descriptive Analysis

Sep 4, 2026

The authors aim to describe the age-associated distribution of primordial follicle density (PFD) in ovarian cortical tissue from post-pubertal females undergoing cryopreservation, particularly focusing on individuals aged 20-34 years. Their findings indicate a nonlinear decline in PFD with age, revealing a median decrease from 1.18 follicles/mm² at age 20 to 0.49 follicles/mm² at age 34. The study highlights the need for larger multicenter research to better understand the implications of PFD on ovarian tissue transplantation outcomes.

Multicenter Assessment of Outcomes After Intended or Non-selective Transfer of Whole Chromosome and Segmental Aneuploid Embryos

Sep 1, 2026

The authors aimed to evaluate the clinical outcomes of embryos classified as non-mosaic whole chromosome aneuploid (WCA) versus segmental aneuploid (SA) following preimplantation genetic testing for aneuploidy (PGT-A) in a multicenter study. They found that WCA embryos resulted in no live births and high rates of failed pregnancies, while SA embryos demonstrated a modest live birth rate of 17.1%, suggesting that segmental aneuploid embryos may have clinically meaningful potential compared to their whole chromosome counterparts. These results underscore the importance of PGT-A classification in understanding the reproductive viability of different types of aneuploid embryos.

From Polycystic Ovary Syndrome to Polyendocrine Metabolic Ovarian Syndrome: A Systematic Search and Historical Account of the Renaming of PCOS

Sep 1, 2026

The authors investigate the historical context and rationale behind the renaming of polycystic ovary syndrome (PCOS) to polyendocrine metabolic ovarian syndrome (PMOS), addressing the inadequacies of the former terminology. Through a systematic review of literature and a global consensus process involving extensive stakeholder engagement, they highlight the need for a more accurate representation of the disorder and its implications for research, education, and clinical practice. The study underscores the importance of this nomenclature change in improving understanding and management of the condition.

Uterine applications of the laparoscopic ultrasound

Sep 1, 2026

The authors aim to demonstrate the setup and application of laparoscopic ultrasound (LUS) during a myomectomy, particularly for patients with a multi-fibroid uterus who have not responded to medical management. The study highlights that LUS provides real-time, high-resolution imaging that enhances the detection of additional fibroids during surgery, significantly improving the surgical outcome by identifying more fibroids than preoperative imaging alone.

The VILOCITY Trial: Validating Incubators in the Lab, Optimizing Culture and Investigating BlasTulation Yield, a Randomized Control Trial (RCT)

Aug 27, 2026

The VILOCITY Trial aimed to determine if using a benchtop incubator for embryo culture would enhance blastulation rates compared to a conventional box incubator in patients undergoing IVF. The study found no significant differences in blastulation rates, fertilization rates, or clinical outcomes between the two incubator types, suggesting that the choice of incubator does not meaningfully impact embryo development or subsequent pregnancy outcomes when other variables are controlled.