July 27, 2026 · Fertility and sterility · DOI: 10.1016/j.fertnstert.2026.07.016

Cumulative probability of a live birth after up to six sequential single euploid embryo transfers

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The authors aimed to estimate the cumulative probability of achieving at least one live birth after up to six sequential single euploid embryo transfers (SET) in patients undergoing in vitro fertilization with preimplantation genetic testing for aneuploidy (PGT-A). They found that the cumulative probability of live birth increased significantly with each transfer, reaching 98.8% after six attempts, while the per-transfer live birth rate stabilized after the second transfer. The study supports the continued transfer of euploid embryos as an effective strategy for patients facing early transfer failures.

Claudia Durbin, Carlos M Parra, Jennifer K Blakemore, Shannon DeVore, Brooke Wertz, M Elizabeth Fino, Frederick Licciardi, Alan Berkeley, Caroline McCaffrey, James A Grifo

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