August 3, 2026 · Fertility and sterility · DOI: 10.1016/j.fertnstert.2026.07.025

AI-based embryo ranking can match or improve traditional assessments but cannot predict an aneuploid chromosomal constitution

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The authors aimed to determine whether AI-based blastocyst ranking tools could outperform traditional non-invasive assessments in prioritizing euploid embryos for transfer. Their findings indicate that while AI models can match or slightly improve upon traditional methods, none of the ranking strategies, including AI, were able to predict aneuploid embryos effectively, even when euploid siblings were present.

Danilo Cimadomo, Marilena Taggi, Federica Innocenti, Valentino Cimadomo, Giovanni Coticchio, Felicia De Falco, Gianluca Nastri, Giulia Fiorentino, Alfredo Stati, Michele Morelli, Maurizio Guido, Alberto Vaiarelli, Jørgen Berntsen, Antonio Capalbo, Filippo Maria Ubaldi, Laura Rienzi

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