August 7, 2026 · Fertility and sterility · DOI: 10.1016/j.fertnstert.2026.07.030

Association between leading follicle size and clinical pregnancy in gonadotropin-stimulated intrauterine insemination cycles with human chorionic gonadotropin trigger: a retrospective cohort study

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The authors aimed to investigate the relationship between leading follicle size at the time of human chorionic gonadotropin (hCG) trigger and clinical pregnancy rates in gonadotropin-stimulated intrauterine insemination (IUI) cycles. Their findings suggest that a leading follicle size of 15-16 mm is optimal for achieving clinical pregnancy, while sizes greater than 17 mm are associated with a decreased probability of pregnancy. This research provides valuable insights for optimizing treatment protocols in gonadotropin-IUI therapies.

Vy D T Ngo, Yen T B Pham, Khoa D Le, Wing C Pun, David Y L Chan, Ronald C C Wang, Jacqueline P W Chung

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