July 23, 2026 · Fertility and sterility · DOI: 10.1016/j.fertnstert.2026.07.015

Safety and Effectiveness of an In Situ-Forming Hydrogel Barrier in Preventing Intrauterine Adhesions After Adhesiogenic Hysteroscopic Procedures: A Multicenter, Randomized, Controlled Trial

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The authors aimed to evaluate the safety and effectiveness of an in situ-forming hydrogel barrier in preventing intrauterine adhesions after adhesiogenic hysteroscopic procedures. The study found that participants receiving the hydrogel barrier had a significantly higher rate of being adhesion-free at second-look hysteroscopy compared to controls, particularly in those undergoing adhesiolysis. No serious adverse events related to the device were reported, indicating its safety for use in this context.

Christina A Salazar, Scott G Chudnoff, Kelly H Roy, Heather G Huddleston, Bala Bhagavath, Peter R Movilla, Pietro Bortoletto, David A Grainger, Charles E Miller, Rebecca Flyckt, Craig J Sobolewski, Nathan Livers, James K Robinson, Vadim V Morozov, Erica F Robinson, Ian B Feldberg, Annette M Fagnant, Malcolm G Munro

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