September 19, 2026 · Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · DOI: 10.1002/jum.70432

Prenatal Ultrasonic Detection of Fetal Cleft Lip and Palate: A 5-Year Retrospective Study

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The authors aimed to evaluate the effectiveness of prenatal ultrasound in detecting fetal cleft lip and/or palate (CL/P) and to analyze the distribution of subtypes, associated malformations, and pregnancy outcomes. Their study found an overall detection rate of 87%, with the highest detection for cleft lip with cleft palate (CLP) at 99.3%, and highlighted the increased risks of structural and genetic anomalies associated with this subtype. The findings suggest that while early detection is possible, there is a significant need for follow-up in cases of isolated cleft lip and palate due to lower detection rates.

Liqin Zeng, Hongwei Lai, Zongjie Weng, Wen Ling, Guorong Lyv, Qiumei Wu

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