September 17, 2026 · Heart rhythm · DOI: 10.1016/j.hrthm.2026.09.018

The Effect of Glucagon-Like Peptide-1 Receptor Agonists versus Sodium-Glucose Cotransporter-2 Inhibitors Alone and in Combination on AF Recurrence and Cardiovascular Outcomes after Catheter Ablation for Atrial Fibrillation

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The authors aimed to evaluate the effects of glucagon-like peptide-1 receptor agonists (GLP-1 RA), sodium-glucose cotransporter-2 inhibitors (SGLT2i), and their combination on atrial fibrillation (AF) recurrence after catheter ablation. Their findings indicated that while AF recurrence rates were similar across all treatment groups, combination therapy significantly reduced all-cause mortality compared to either treatment alone.

Adham Ramadan, Mohamed Doma, Mohammad Hosein Yazdanpanah, Farhan Naeem, Leon M Ptaszek, Jeremy N Ruskin

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