Isolated Phrenic and Vagus Nerve Stimulation and Conduction Suppression Induced by Electroporation Pulses

The authors aimed to investigate how different pulse parameters of biphasic electroporation pulses affect the excitation and conduction suppression of isolated swine phrenic and vagus nerves. They found that stimulation thresholds and conduction suppression were significantly influenced by pulse width and amplitude, with high-amplitude pulses causing reversible conduction suppression. This study provides insights into the neural effects of pulsed field ablation, which may help explain clinical phenomena such as bradycardia and coronary vasospasm.