Heart rhythm
Heart rhythm
Audio Summaries
Every issue of Heart rhythm moves the field forward, but reading every paper cover-to-cover isn't realistic. OSLR turns each article into a 3-minute audio summary so you can stay current while you commute, round, or work out.
Recent summaries
The latest articles summarized from Heart rhythm.
Antisense-Mediated Gene Therapy Targeting DMPK Restores Cardiac Ion Channel Function and Electrical Stability in Myotonic Dystrophy Type 1
Jun 5, 2026
The authors aimed to evaluate the efficacy of the antisense oligonucleotide IONIS-486178 in targeting mutant DMPK transcripts to restore cardiac function in myotonic dystrophy type 1 (DM1). Their findings demonstrate that treatment significantly reduced DMPK levels, corrected ion channel mis-splicing, and restored normal ionic currents and action potential characteristics in human induced pluripotent stem cell-derived cardiomyocytes, thereby reducing arrhythmogenic events. This study supports the potential of antisense-mediated gene therapy as a therapeutic strategy for preventing cardiac complications associated with DM1.
Impact of Anxiety and Depression in Patients with Atrial Fibrillation: Insights from Two International Prospective Registries
Jun 5, 2026
The authors aimed to investigate the impact of anxiety and depression on clinical outcomes in patients with atrial fibrillation (AF) by comparing characteristics and outcomes between those with and without these psychological conditions. Their findings revealed that patients with symptoms of anxiety and/or depression experienced significantly worse outcomes, including higher risks of all-cause death and major adverse cardiovascular events, particularly in those with moderate-to-severe symptoms. This underscores the importance of incorporating psychological assessments into the management of AF.