RhD-Positive Whole Blood for Patients With Reproductive Potential After Two Randomized Trials of Prehospital Trauma Resuscitation

The authors investigate the ethical implications of using RhD-positive whole blood for trauma resuscitation in RhD-negative patients with reproductive potential, particularly in light of recent trials showing no survival advantage over component therapy. They argue that the risk of alloimmunization and potential future harm to pregnancies outweighs the benefits of using RhD-positive blood, advocating for the default use of RhD-negative products when available. The paper emphasizes the need for ethical standards and protocols to protect vulnerable patients during emergency care.