Population Prevalence and Incident HPA-1a Alloimmunisation in Pregnancy: A Prospective, Multi-Ethnic, Natural History Study
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The authors aimed to determine the prevalence of higher risk for HPA-1a alloimmunisation and the development of foetal-neonatal alloimmune thrombocytopaenia (FNAIT) among a diverse cohort of pregnant women. The study found that only 1.7% of participants were of the HPA-1b/1b genotype, with a small percentage of those at higher risk developing anti-HPA-1a antibodies post-partum, highlighting the rarity of this condition and its varying prevalence among different racial and ethnic groups.
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