Timing of Initiation of Methadone Take-Home Dosing

The authors aimed to determine the impact of different initiation times for methadone take-home dosing on all-cause mortality and treatment discontinuation among individuals undergoing opioid use disorder treatment in British Columbia, Canada. Their findings indicate that initiating take-home doses within 5 to 12 weeks and 13 to 24 weeks after induction significantly reduced both mortality and discontinuation rates compared to no take-home dosing, highlighting the potential benefits of refining clinical guidelines for methadone treatment.