August 24, 2026 · JAMA internal medicine · DOI: 10.1001/jamainternmed.2026.3983

Epidemiologic Study of Transfusion-Related Alpha-Gal Syndrome

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This study investigates the association between the prevalence of alpha-gal syndrome (AGS) and allergic transfusion reactions (ATRs) in patients with blood type O receiving B or AB blood products. The authors found that in AGS high-prevalence regions, there was a significantly higher risk of ATRs among these patients compared to those receiving O units, suggesting that transfusion-related alpha-gal syndrome (TRAGS) may be a distinct risk factor in these areas. The findings indicate the need for blood collectors and transfusion services to implement preventive measures in regions where AGS is prevalent.

Richard M Kaufman, Anne G Hoen, Jenna Khan, C Michael Knudson, Ryan A Metcalf, Andres E Mindiola Romero, Allison Mo, Richard Schäfer, Minoko Takanashi, Nancy M Dunbar, UPTICK Study Group; for the Biomedical Excellence for Safer Transfusion (BEST) Collaborative, Richard M Kaufman, Anne G Hoen, Jenna Khan, C Michael Knudson, Ryan A Metcalf, Andres E Mindiola Romero, Allison Mo, Richard Schäfer, Minoko Takanashi, Sajjad Afraz, Elizabeth S Allen, Jennifer Andrews, Konstanze Aurich, John Casey, Claudia S Cohn, Jensyn K Cone Sullivan, Clara C Cousins, Elizabeth P Crowe, Valeria De Giorgi, Meghan Delaney, Regina M DelBaugh, Colleen W Gilstad, Alexander Gofton, Jeanne E Hendrickson, Kate Hill, Keenan O Hogan, Catherine Humbrecht, Kazuhiko Ikeda, Cyril Jacquot, Ayda Javanbakht, Justin E Juskewitch, Wen Lu, Monique M Menzies Wojtowicz, Maureen J Miller, Georgia Mills, Anna C Nelson, Monica B Pagano, Marie C Pauly, Jessica L Poisson, Jay S Raval, Nabiha H Saifee, Nikitha Samy, Tomohiko Sato, Yoshinori Takeda, Suzanne R Thibodeaux, Pierre Tiberghien, Sheryl van Nunen, Mrigender S Virk, Kamille West-Mitchell, Erica M Wood, Jun Yamanouchi, Satoshi Yoshihara, X Long Zheng, Alyssa Ziman, Nancy M Dunbar

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Epidemiologic Study of Transfusion-Related Alpha-Gal Syndrome

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