August 30, 2026 · JAMA internal medicine · DOI: 10.1001/jamainternmed.2026.4773

Specialist Referral for Cardiovascular Risk in Patients With Prostate Cancer: A Randomized Clinical Trial

Listen to this summary

This randomized clinical trial aimed to determine whether routine referral of prostate cancer patients to cardiovascular specialists would improve cardiovascular risk factor control and reduce adverse cardiovascular outcomes compared to usual care. The results indicated that while the intervention led to better cholesterol management, it did not significantly affect the incidence of major cardiovascular events such as death, myocardial infarction, or stroke. Thus, the study suggests that specialist referral may enhance specific risk factor control but does not guarantee a reduction in clinical cardiovascular events.

Darryl P Leong, Celestia Higano, Cristina Cano Garcia, Vincent Fradet, D Robert Siemens, Tamim Niazi, Bobby Shayegan, Avirup Guha, Filipe Cirne, Joseph B Selvanayagam, Philippe D Violette, Felipe H Valle, Luke T Lavallée, Emmanuelle Duceppe, Patrick Anderson, Denis Xavier, Jose Patricio Lopez-Lopez, Nicolas Villareal Trujillo, Ariel Galapo Kann, Rafaela K Piccoli, Marina Mourtzakis, David Sarid, Srivatsa Narasimha, Patrick P W Luke, Ludhmila A Hajjar, Himu Lukka, Laurence Klotz, Kumar Balasubramanian, Rajibul Mian, Steven Agapay, Sumathy Rangarajan, Sarah Karampatos, Kelvin K H Ng, Alvaro Avezum, P J Devereaux, Jehonathan H Pinthus, RADICAL PC Investigators

This is one of 33,000+ journals available on OSLR. Try it free for 14 days.

Free 14-day trial. 33,000+ journals. Cancel anytime.

14-day free trial. No commitment.

“

"Oslr has become part of my weekly routine on my day off. The clinical relevance of the summaries is outstanding — I'd rate it 9/10. Being able to consume research hands-free is a huge advantage for busy physicians."

Dr. Jennifer Thompson

Dr. Jennifer Thompson

Portland, OR

Stay current without falling behind

33,000+ journals. 3-minute audio summaries. Free for 14 days.

Download on the App StoreGet it on Google Play