September 6, 2026 · European heart journal · DOI: 10.1093/eurheartj/ehag611

Targeted vitamin D supplementation and major adverse cardiovascular events after myocardial infarction: the TARGET-D trial

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The TARGET-D trial aimed to determine whether targeted vitamin D supplementation could reduce major adverse cardiovascular events in patients following a myocardial infarction. Despite high prevalence of vitamin D insufficiency among participants, the study found no significant difference in major cardiovascular outcomes between those receiving targeted vitamin D management and those receiving usual care. However, a notable reduction in myocardial infarction rates was observed in the vitamin D group compared to usual care.

Heidi T May, Viet T Le, Jeffrey L Anderson, Leslie Iverson, Tami L Bair, Stacey Knight, Kirk U Knowlton, Benjamin E Peterson, Joseph B Muhlestein

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