Reconciling evidence-based and personalized medicine: perspectives in heart failure and cardiomyopathies

The authors explore how to reconcile evidence-based medicine (EBM) with personalized medicine (PM) in the management of heart failure and inherited cardiomyopathies, given the tension between population averages and individual patient needs. They examine the philosophical and practical implications of this interplay and propose a framework to harmonize both approaches, aiming to enhance patient outcomes in cardiovascular care. The review highlights the need for strategies that integrate the strengths of EBM and PM, particularly in the context of conditions with variable individual trajectories.