Circulating Dipeptidyl Peptidase 3 levels, an Antagonist of Angiotensin-(1-7), in Acute Heart Failure: Insights from the PUSH-AHF trial
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The authors aimed to investigate the levels of circulating dipeptidyl peptidase 3 (cDPP3) in patients with acute heart failure and their association with clinical characteristics, decongestive response, and outcomes. They found that higher cDPP3 concentrations were linked to impaired kidney function and reduced diuretic response, while natriuresis-guided therapy improved decongestion across different cDPP3 levels. The study suggests that further research is needed to clarify the clinical significance of cDPP3 in acute heart failure.
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