Perimenopause and metabolic vulnerability: hormones, body composition and lifestyle changes

The authors investigate how perimenopause, marked by hormonal fluctuations and metabolic changes, contributes to increased metabolic vulnerability in women, particularly through alterations in body composition and energy metabolism. Their review highlights the role of declining estrogen in driving these changes and emphasizes the importance of lifestyle interventions, such as resistance training and adherence to a Mediterranean diet, in mitigating long-term cardiometabolic risks. Ultimately, they advocate for recognizing perimenopause as a critical period for early detection and prevention of metabolic dysfunction.