September 14, 2026 · Climacteric : the journal of the International Menopause Society · DOI: 10.1080/13697137.2026.2715238

Effect of fezolinetant on sleep, health-related quality of life and work productivity

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The study aimed to assess the effects of fezolinetant on sleep disturbances and work productivity in women experiencing moderate to severe vasomotor symptoms (VMS) due to menopause. Results indicated that fezolinetant significantly improved sleep outcomes and work productivity over 12 weeks, with sustained benefits observed at 52 weeks, highlighting a correlation between reductions in VMS and enhancements in both sleep quality and work performance.

Antonio Cano, Genevieve Neal Perry, Karla Martins, Antonia Morga, Arianne Schild, Rossella E Nappi, Marla Shapiro, Nanette Santoro

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