August 17, 2026 · JAMA internal medicine · DOI: 10.1001/jamainternmed.2026.3831

Serologic Immunity to Hepatitis A and B in US Adults and High-Risk Populations

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The authors aimed to estimate the prevalence and factors associated with serologic immunity to hepatitis A (HAV) and hepatitis B (HBV) among US adults, particularly in high-risk populations. The study found that overall immunity levels were suboptimal, with 39.5% for HAV and 27.1% for HBV, highlighting significant gaps in protection, especially among high-risk groups. These results underscore the need for targeted vaccination strategies to improve immunity against these viral infections.

Giovanni A Roldan, Jesse Fletcher, Timothy Davie, Thomas M Leventhal, John R Lake, Prowpanga Udompap

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