August 5, 2026 · Surgery · DOI: 10.1016/j.surg.2026.110443

Preoperative prebiotic supplementation alleviates colitis and improves anastomotic healing associated with modulation of the gut microbiota in rats

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The authors investigate whether preoperative prebiotic supplementation can alleviate colitis and enhance anastomotic healing in a rat model, particularly in the context of bacterial dysbiosis associated with inflammatory bowel disease. Their findings suggest that a complex prebiotic supplement improves microbial diversity, protects against colitis-related damage, and strengthens anastomotic integrity, indicating its potential role in microbiota-targeted prehabilitation for colorectal surgery patients.

Szabina Kovacs, Krisztian Szigeti, Krisztian Laczi, Balint Hofmeister, Nora Makra, Zsuzsanna A Dunai, Eszter Ostorhazi, Andras Budai, Mark Juhasz, Balazs Banky, Attila Szijarto, Andras Fulop

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