PRSS1<sup>A16V</sup> germline mutation is common in a cohort of intraductal papillary mucinous neoplasms of the pancreas
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The authors aimed to investigate the genetic alterations associated with intraductal papillary mucinous neoplasms (IPMNs) of the pancreas, specifically exploring the role of the PRSS1<sup>A16V</sup> germline mutation in these lesions. Their findings revealed that this mutation is present in a subset of IPMNs and is linked to clinical symptoms and imaging features indicative of early chronic pancreatitis, suggesting that inflammation may play a role in the biology and heterogeneity of these neoplasms.
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