Mechanobiological Dysregulation of Fibroblasts and Extracellular Matrix Failure in Pelvic Organ Prolapse

This narrative review investigates the role of fibroblast mechanobiology and extracellular matrix (ECM) dysfunction in the pathogenesis of pelvic organ prolapse (POP). The authors aim to elucidate how impaired mechanical loading affects fibroblast behavior and ECM remodeling, proposing a multiscale framework that links these processes to the progression of POP. Their findings suggest that dysregulated fibroblast mechanobiology is a critical factor in the development of this condition, potentially guiding future therapeutic strategies.