International urogynecology journal
Audio Summaries

Multimodal Biomarker and Ultrasound Profiling in Women with Overactive Bladder: A Prospective Case-Control Study

Aug 7, 2026

This study aimed to establish a multimodal biological profile for women with overactive bladder (OAB) by evaluating urinary and serum biomarkers alongside ultrasonographic bladder parameters. The findings revealed significant elevations in neurotrophins and oxidative stress markers in OAB patients compared to healthy controls, with serum NGF showing the highest diagnostic accuracy. The authors conclude that these exploratory results highlight a distinct biological profile in OAB, warranting further validation in larger cohorts before clinical application.

Neuromodulation for Lower Urinary Tract Dysfunction: Mechanisms, Modalities, and Patient Selection

Aug 5, 2026

The authors aim to evaluate the role of neuromodulation in treating lower urinary tract dysfunction (LUTD) and to identify optimal patient selection criteria. Through a narrative review of existing literature and guidelines, they highlight the effectiveness and safety of various neuromodulation techniques, particularly sacral and tibial nerve stimulation, while emphasizing the need for improved patient stratification and standardized outcomes in future studies.

The Effect of Midurethral Slings on Overactive Bladder Medication Use in Women with Mixed Urinary Incontinence

Aug 4, 2026

The authors aimed to determine how the placement of midurethral slings (MUS) affects the need for overactive bladder (OAB) medications in women with mixed urinary incontinence (MUI). Their findings revealed that postoperative treatment trajectories varied, with some women initiating, continuing, or discontinuing OAB medications, highlighting the complexity of managing OAB symptoms after MUS placement. Overall, the study suggests that while many patients maintained their medication status, a notable subset experienced changes in their pharmacological treatment needs postoperatively.

Mechanobiological Dysregulation of Fibroblasts and Extracellular Matrix Failure in Pelvic Organ Prolapse

Aug 4, 2026

This narrative review investigates the role of fibroblast mechanobiology and extracellular matrix (ECM) dysfunction in the pathogenesis of pelvic organ prolapse (POP). The authors aim to elucidate how impaired mechanical loading affects fibroblast behavior and ECM remodeling, proposing a multiscale framework that links these processes to the progression of POP. Their findings suggest that dysregulated fibroblast mechanobiology is a critical factor in the development of this condition, potentially guiding future therapeutic strategies.

Efficacy and Safety of Radiofrequency as a Treatment Modality for Genitourinary Syndrome of Menopause: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Jul 30, 2026

The authors aimed to evaluate the efficacy and safety of radiofrequency (RF) therapy for managing genitourinary syndrome of menopause (GSM) compared to other treatment modalities. Their systematic review and meta-analysis of eight randomized controlled trials found that RF therapy significantly improved sexual function compared to vaginal estrogen and placebo/moisturizer, while showing comparable results to laser therapy. Additionally, RF therapy was associated with mild adverse events, indicating a favorable safety profile.

Autologous Semitendinosus Hamstring Tendon Transplant for Female Urinary Stress Incontinence Treatment (Anat-SUBLIM: Anatomy for Suburethral Ligamentoplasty): A Cadaver Model

Jul 29, 2026

This cadaveric study aimed to compare the morphometric characteristics of semitendinosus (STT) and gracilis (GT) hamstring tendons for their potential use as autologous alternatives to synthetic slings in treating female stress urinary incontinence (SUI). The findings revealed that STT has greater length and thickness than GT, making it a viable option for suburethral placement via vaginal and retropubic approaches. The successful harvesting and placement of STT in this model suggest its potential as an effective autologous solution for SUI treatment.

Hip Muscle Strengthening and Electrical Stimulation as Adjuncts to Pelvic Floor Training on Urinary Incontinence

Jul 29, 2026

The authors aimed to determine whether adding hip muscle strengthening exercises or intravaginal electrical stimulation (ES) to biofeedback-assisted pelvic floor muscle training (BF-PFMT) could enhance outcomes for women with stress and mixed urinary incontinence. The study found that while all interventions improved pelvic floor function and quality of life, the combination of BF-PFMT with hip strengthening exercises resulted in the most significant increase in pelvic floor muscle strength. Overall, the findings suggest that adjunctive therapies can enhance the effectiveness of standard pelvic floor training.

Urinary Incontinence Among Female Patients with Lichen Sclerosus: An Updated Systematic Review and Meta-Analysis

Jul 28, 2026

This systematic review and meta-analysis aimed to quantify the prevalence of urinary incontinence (UI) among female patients with lichen sclerosus (LS) and assess the associated risk. The findings indicate that women with LS have a significantly higher prevalence of UI, with a 68% increased risk compared to non-LS controls. The authors emphasize the importance of integrating urological assessments into the management of LS due to this association.

Obliterative Repair for Pelvic Organ Prolapse: Retrospective Cohort Comparing Three Techniques

Jul 27, 2026

This study aimed to compare the outcomes of three different obliterative surgical techniques for advanced pelvic organ prolapse (POP) in women who do not desire vaginal intercourse. The authors found that all techniques—colpocleisis (vault), colpocleisis with vaginal hysterectomy, and Le Fort colpocleisis—demonstrated high rates of both objective and subjective cure with minimal complications, although the length of hospitalization varied significantly among the procedures. These results support the use of obliterative surgery as a safe and effective treatment option for advanced POP.

Late Omental Evisceration Following Sacrospinous Ligament Fixation: A Case Report and a Focused Literature Review

Jul 27, 2026

This case report investigates the rare occurrence of late vaginal vault dehiscence with omental evisceration following sacrospinous ligament fixation (SSLF) in a menopausal patient. The authors aim to highlight the importance of recognizing this condition as a surgical emergency and provide insights into its management, emphasizing the need for long-term monitoring to prevent complications such as bowel involvement. The accompanying literature review further explores delayed presentations and potential triggers for this complication.