May 7, 2026 · International urogynecology journal · DOI: 10.1007/s00192-026-06536-4

Comparative Efficacy of Tadalafil and Amitriptyline in Female Interstitial Cystitis/Bladder Pain Syndrome: Double-Blind Randomized Trial

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This study aimed to compare the efficacy and safety of tadalafil, amitriptyline, and their combination in treating female interstitial cystitis/bladder pain syndrome (IC/BPS). The results indicated that tadalafil, either alone or in combination with low-dose amitriptyline, significantly improved symptoms and urinary function compared to amitriptyline alone, suggesting it as a safe and effective treatment option for this condition.

Noran N Makled, Mirhan N Makled, Tamer E Helmy, Mahmoud R El-Kenawy, Ahmed S El-Hefnawy

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