July 30, 2026 · Urogynecology (Philadelphia, Pa.) · DOI: 10.1097/SPV.0000000000001905

Reduced-Dose OnabotulinumtoxinA for Urgency Incontinence in Older Women: Methods

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The authors aim to evaluate the efficacy and safety of a reduced dose (50 units) of onabotulinumtoxinA compared to the standard dose (100 units) for treating overactive bladder symptoms in women aged 70 and older with urgency urinary incontinence. This randomized controlled trial will assess changes in quality of life and other patient-reported outcomes, while also considering factors such as frailty and adverse events. The study seeks to provide valuable insights into treatment options for this often-overlooked demographic.

Anne C Cooper, Holly E Richter, Shawn A Menefee, David D Rahn, Sara Cichowski, Isuzu Meyer, Jonathan P Shepherd, Christopher Chermansky, E Ann Gormley

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