July 28, 2026 · Regional anesthesia and pain medicine · DOI: 10.1136/rapm-2026-107976

Efficacy of systemic lidocaine versus ultrasound-guided adductor canal block for patients undergoing total knee arthroplasty: a randomized, double-blinded, non-inferiority study

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This study aimed to determine whether intravenous lidocaine is non-inferior to ultrasound-guided adductor canal block in managing postoperative pain and opioid consumption in patients undergoing total knee arthroplasty. The results indicated that while adductor canal block provided superior immediate analgesia in the post-anesthesia care unit, both methods were comparable in terms of opioid consumption and recovery quality over the first 24 hours, suggesting that lidocaine is a viable alternative when regional anesthesia is not an option.

Vendhan Ramanujam, Arvind Murthy, Kristopher Davignon, Abby Frenkel, Valentin Antoci, Eric Cohen, Alison Liu, Alexander D Cohen, Gildasio De Oliveira, Mark C Kendall

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