Intensive Blood-Pressure Control for the Prevention of Major Cardiovascular Events in Patients with Type 2 Diabetes: Rationale, Design and Baseline Characteristics of the OPTIMAL-DIABETES Randomized Trial

The OPTIMAL-DIABETES trial aims to determine whether targeting a systolic blood pressure (SBP) of less than 120 mmHg reduces major cardiovascular events more effectively than a target of less than 140 mmHg in patients with type 2 diabetes and high cardiovascular risk. This multicenter, randomized clinical trial involves a diverse population and will assess outcomes over a maximum follow-up of 48 months. The findings are expected to provide important insights into the optimal blood pressure management strategy for this high-risk group.