July 31, 2026 · American heart journal · DOI: 10.1016/j.ahj.2026.107548

Reconsidering Fibrinolysis in Selected Patients with Non-ST-Elevation Acute Coronary Syndrome: A Hypothesis-Generating, Research-Based Framework

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The authors explore whether fibrinolytic therapy could be beneficial for selected patients with non-ST-elevation acute coronary syndrome (NSTE-ACS) who are identified as having acute coronary artery occlusion through advanced diagnostic techniques, such as artificial intelligence-enhanced electrocardiography. They propose a research-based framework to investigate the potential risks and benefits of this therapy in situations where timely angiographic evaluation or percutaneous coronary intervention is unavailable. The article aims to generate hypotheses for future studies rather than suggesting immediate changes to clinical practice.

Cesar Rodrigo Zoni, Debabrata Mukherjee, Martha Gulati

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