Impact of estimated total blood volume on NT-proBNP response to angiotensin receptor-neprilysin inhibition in acute heart failure: insights from the PREMIER study
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The authors aimed to investigate whether estimated total blood volume (TBV) influences the reduction of NT-proBNP levels in acute heart failure patients treated with sacubitril/valsartan (Sac/Val) compared to those receiving ACEI/ARB therapy. Their analysis of data from the PREMIER study found that higher TBV was associated with a greater reduction in NT-proBNP levels after Sac/Val, particularly in patients with left ventricular ejection fraction (LVEF) ≥40%. These results suggest a potential relationship between TBV and biomarker response, warranting further validation.
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