July 22, 2026 · JAMA · DOI: 10.1001/jama.2026.8977

Mechanical Thrombectomy in Ischemic Stroke With a Medium or Distal Arterial Occlusion: The DISCOUNT Randomized Clinical Trial

Listen to this summary

The DISCOUNT randomized clinical trial aimed to evaluate the efficacy and safety of mechanical thrombectomy in patients with acute ischemic stroke due to medium or distal vessel occlusions, comparing it to medical treatment alone. The trial found that thrombectomy did not result in a significantly higher rate of good clinical outcomes at three months, while also revealing a higher incidence of hemorrhagic complications associated with the procedure. Consequently, the authors concluded that thrombectomy may not be beneficial for this patient population.

Frédéric Clarençon, Fouzi Bala, Amandine Baptiste, Marco Pasi, Gaultier Marnat, Igor Sibon, Benjamin Gory, Sébastien Richard, Raoul Pop, Valérie Wolff, Cédric Fauché, Matthias Lamy, Vincent Costalat, Caroline Arquizan, Christine Rodriguez-Régent, Guillaume Turc, Christophe Cognard, Louis Fontaine, Federico Di Maria, Bertrand Lapergue, Nicolas Bricout, Hilde Henon, Titien Tuilier, Aymeric Wittwer, Pierre Louis Alexandre, Solène De Gaalon, Laurent Spelle, Christian Denier, Emmanuel Chabert, Anna Ferrier, Aymeric Rouchaud, Francisco Macian-Montoro, Sébastien Soize, Solène Moulin, William Boisseau, Candice Sabben, Charlotte Barbier, Marion Boulanger, Omer Faruk Eker, Tae-Hee Cho, Jean-Christophe Gentric, Serge Timsit, Marc-Antoine Labeyrie, Peggy Reiner, Fernando Pico, Isabelle Durand-Zaleski, Sonia Alamowitch, Agnès Dechartres, DISCOUNT Investigators

This is one of 33,000+ journals available on OSLR. Try it free for 14 days.

Free 14-day trial. 33,000+ journals. Cancel anytime.

14-day free trial. No commitment.

"Oslr has become part of my weekly routine on my day off. The clinical relevance of the summaries is outstanding — I'd rate it 9/10. Being able to consume research hands-free is a huge advantage for busy physicians."

Dr. Jennifer Thompson

Dr. Jennifer Thompson

Portland, OR

Stay current without falling behind

33,000+ journals. 3-minute audio summaries. Free for 14 days.

Download on the App StoreGet it on Google Play