Prognostic Value of Blood-Based P-Tau217 Levels for Progression to Cognitive Impairment
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The authors aimed to estimate the absolute risk of progression to cognitive impairment and rates of cognitive decline in cognitively unimpaired older adults based on plasma levels of phosphorylated tau 217 (p-tau217). They found that higher baseline p-tau217 levels were significantly associated with an increased risk of progression to cognitive impairment and faster cognitive decline over time. These findings suggest the potential use of p-tau217 as a prognostic biomarker in clinical settings, although further validation in broader populations is necessary.
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