July 17, 2026 · The American journal of sports medicine · DOI: 10.1177/03635465261459242

A Prospective Clinical and Magnetic Resonance Imaging-Based Follow-up Beyond 10 Years After Arthroscopic Matrix-Induced Autologous Chondrocyte Implantation

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The authors aimed to evaluate the long-term clinical and radiological outcomes of arthroscopically performed matrix-induced autologous chondrocyte implantation (MACI) on the femoral condyles, assessing patient-reported outcomes and MRI findings over a mean follow-up of 13.6 years. Results indicated significant improvements in patient satisfaction and knee function, although some deterioration in MRI scores was noted over time, with a low graft failure rate of 4.4%. Overall, the study suggests that arthroscopic MACI can lead to favorable long-term outcomes for patients.

Jay R Ebert, Peter K Edwards, Sven Klinken, David J Wood, Gregory C Janes

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